Electrochemical oxidation of meglumine in a pharmaceutical formulation using a nanocomposite anode

The electrocatalytic oxidation of meglumine and gadoterate (Gd-DOTA) on a TiO2-Ni(SO4)0.3(OH)1.4 composite anode was investigated in alkaline medium (5 M KOH) using cyclic voltammetry chronoamperometry. prepared by hydrothermal method the morphology structure produced nanoparticles were studied scanning electron microscopy with energy-dispersive X-ray spectroscopy, diffraction, atomic force microscopy, BET surface area analysis Fourier transform infrared spectroscopy. characterization revealed formation Ni(SO4)0.3(OH)1.4 nanobelts dispersed TiO2 nanoaggregates. coated onto porous graphite rod, showing good adherence without requiring any binder (according to their anodic cathodic charges). supported electrocatalytic, allowing meglumine, either as pure reagent or contained solutions. Electrochemical methods allowed determining kinetic parameters, such transfer coefficient α, total number electrons n standard heterogeneous rate constant k0 for reaction meglumine. chronoamperometric tests informed about stability upon at +0.6 V 10 h. electrochemical commercial pharmaceutical formulation (Dotarem®) corroborated via ultra-high performance liquid chromatography coupled electrospray ionization quadrupole time-of-flight mass spectrometry.